Journal: Pharmacology Research & Perspectives
Article Title: Targeting Inflammatory and Oxidative Pathways in Idiopathic Pulmonary Fibrosis: Synergistic Effects of Quercetin and Pirfenidone in Modulating Nrf2/ PPAR ‐γ and TLR ‐4/ NF ‐ κB Pathways
doi: 10.1002/prp2.70229
Figure Lengend Snippet: Effect of pirfenidone and quercetin on the level of pulmonary inflammatory drive in the different experimental groups: (A) Represents the quantification of TNF‐α in lung tissue. (B) Illustrates the concentrations of IL‐1β and (C) shows IL‐6 expression. All measured in pg/g protein. Bars represent the average of 5 measurements ( n = 5) and error bars represent standard error (SEM). Significance is denoted by symbols above the bars: * p < 0.05, ** p < 0.01, *** p < 0.001 compared to the control group; + p < 0.05, ++ p < 0.01, +++ p < 0.001 compared to the BLM group; # p < 0.05, ## p < 0.01, ### p < 0.001 compared to the Pirf group, $ p < 0.05, $$ p < 0.01, $$$ p < 0.001 compared to the Quer group.
Article Snippet: The assay was performed using ELISA kits for rat TNF‐α, cat. no.: ELK1396 (ELK Biotechnology, Wuhan, Hubei, China), rat IL‐1β ELISA Kit, cat. no.: ER1094 (Fine Biotech, Wuhan, Hubei, China), and rat IL‐6, cat. no.: E‐EL‐R0015 (Elabscience Biotechnology, USA).
Techniques: Expressing, Control